MicroRNA expression profile reveals miR-17-92 and miR-143-145 cluster in synchronous colorectal cancer. Medicine 2015;94:e1297. Loftas

The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic transformation, including evasion of apoptosis. In the current study, we show a new role of miR-17-92 in inhibiting oncogenic ras -induced senescence.

Now more than 300 miRNA clusters are found in the human genome, including miR-183-96-182 cluster, miR-35-41 cluster, miR-17-92 cluster and so on. MiR-17-92 cluster is involved in the development of multiple organs in mammals and closely related to the development and occurrence of tumors, thus it receives widespread attention in the world [ 9 ]. Olive et al. (2009) approached the dissection of the miR-17-92 cluster from the opposite side, by overexpression of different miRNA components in the Eμ-Myc-induced B-cell lymphomas.

Mirna 17-92 cluster

MiR-17-92 cluster is a direct Nanog target in NSCWe first validated profiling data by single assay QPCR ( Figure 2A). To verify a direct transcriptional Nanog control on the two miRNA clusters, miR-17-92 and miR-106b-25, their genomic cis-regulatory regions were investigated. Thus, miRNA miR‐17‐92 cluster may not be a key factor regulating imiqumod‐induced psoriasis‐like dermatitis. 1 Background.

5. 140050381. Yuan, Zhou, Zong-Guang och Sun, Xiao-Feng, MicroRNA Expression Profile Reveals miR-17–92 and miR-143–145 Cluster in Synchronous Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer om NKS kan bidra till innovationskraften i ett Life Science kluster under stark sk mikroRNA-kluster, miR 17-92, som i sin tur aktiveras av MYCN-proteinet.

Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes. We specifically deleted the miR-17-92 cluster in oligodendrocytes using 2,3 -cyclic nucleotide 3 phosphodiesterase (Cnp)-Cre mice. Absence of miR-17-92 leads to a reduction in oligodendrocyte number in vivo and we

2013-06-25 Members of the miRNA gene cluster can coordinate the regulation of certain processes or play a similar role in the same biological process, ensuring biological activity occurs in a normal and orderly fashion. miR-17-92 encodes a miRNA precursor and produces 7 mature miRNA molecules that belong to 4 miRNA … Interestingly, deletion or overexpression of miR-17- 92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis- like dermatitis develop-ment in the mutant mice compared with wild-type littermates.

1542 dagar, miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in

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A high-level of miR-17-92 cluster expression also results in the poor survival rate of patients with MCL . Interestingly, deletion or overexpression of miR-17- 92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis- like dermatitis develop-ment in the mutant mice compared with wild-type littermates. Thus, miRNA miR-17- 92 cluster Members of the miRNA gene cluster can coordinate the regulation of certain processes or play a similar role in the same biological process, ensuring biological activity occurs in a normal and orderly fashion. miR-17-92 encodes a miRNA precursor and produces 7 mature miRNA molecules that belong to 4 miRNA families.
Bertil nilsson hh

miR-17-92 encodes a miRNA precursor and produces 7 mature miRNA molecules that belong to 4 miRNA … The miR-17~92 cluster in cancer pathogenesis. First evidence that the miR-17~92 cluster may be involved in tumori-genesis was provided by studies showing that the C13orf25 locus, which encodes the primary transcript of the miR-17~92 cluster, is frequently … Thus, miRNA miR‐17‐92 cluster may not be a key factor regulating imiqumod‐induced psoriasis‐like dermatitis. 1 Background. Psoriasis is an immune‐mediated inflammatory skin disease, characterized by keratinocyte hyperproliferation and altered differentiation, This miRNA dose-dependent target selection was also confirmed in other target genes, including CCND1, CDKN1 and E2F1.

MicroRNA-17-92 (miRNA-17-92 or miR-17-92) is a miRNA cluster that regulates cell growth and immunity, but the role of miR-17-92 cluster in keratinocytes and its relation to skin diseases have not been well investigated.
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Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA

The mir-17-92 cluster, which is transcribed as a polycistronic unit from chromosome 13, comprises 7 individual miRNAs (mir-17, mir-18a, mir-19a, mir-19b-1, mir-20a, and mir-92a-1; ref. 52).

Klusteret miR-17/92: en omfattande uppdatering av dess genomik, genetik, funktioner Genomisk representation av den humana miR-17-92-klustervärdgenen

However, the in vivo effect of the miR-17-92 cluster on adult neurogenesis in the hippocampus and consequent neurobehavioral function, especially learning and memory, has not been investigated. In the present study, by specific ablation of this cluster in 2009-02-24 Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes. We specifically deleted the miR-17-92 cluster in oligodendrocytes using 2,3 -cyclic nucleotide 3 phosphodiesterase (Cnp)-Cre mice. Absence of miR-17-92 leads to a reduction in oligodendrocyte number in vivo and we Abstract: The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster expression. Our deletion analysis of the Overexpression of the miR-17-92 cluster in MLL-rearranged leukemias.

The miRNA-17-92 cluster may be highly expressed in a wide range of tumor cells and types of cancer, such as lung, breast, pancreatic, prostate and thyroid cancer, as well as lymphomas (7,14).